Should turn on Loot respawn setting?

I'm a newbie in project zomboid. Just played 15 hours in one game until die by infection on apocalypse difficulty, yay.

When I was going to make a new world for a fresh start, I decide check custom sandbox option, and I've seen ''Loot respawn'' option off. I should turn it on? Idk how ''limited'' are the resources, and I usually aim for play the same game for looooong time (until die, he).

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